This hearty casserole is a comforting and satisfying way to transform leftover chicken into a warm, family-friendly meal. With tender chicken, soft biscuits, creamy sauce, and melted cheese, this dish brings together familiar flavors in a simple baked format that works well for weeknight dinners, gatherings, or meal prep. The preparation is straightforward, and the result is a filling casserole that feels both homemade and dependable, making it a favorite for cooks who value practicality without sacrificing flavor.
This recipe keeps the structure uncomplicated while delivering a rich, balanced texture in every bite. The biscuits bake directly in the creamy mixture, absorbing flavor as they rise, while the cheese adds depth and a golden finish. The result is a cohesive dish that slices easily and serves beautifully straight from the oven.
Chicken Biscuit Casserole
Ingredients
Cooked chicken (shredded or cubed): 2 cups
Cream of chicken soup: 1 can (10.5 oz)
Sour cream: 1/2 cup
Cheddar cheese, shredded: 1 1/2 cups, divided
Refrigerated biscuits: 1 can (16.3 oz)
Milk: 1/4 cup
Garlic powder: 1/2 teaspoon
Onion powder: 1/2 teaspoon
Salt: to taste
Pepper: to taste
Butter, melted: 2 tablespoons
Fresh parsley or chives (optional): for garnish
Instructions
Preheat the oven
Begin by setting the oven to 375°F (190°C). Lightly grease a 9×13-inch baking dish to prevent sticking and ensure easy serving once the casserole is baked.
Prepare the filling
In a large mixing bowl, combine the cream of chicken soup, sour cream, milk, garlic powder, onion powder, salt, and pepper. Stir until the mixture is smooth and evenly blended. This base creates the creamy texture that binds the casserole together while carrying flavor throughout the dish.
Add the cooked chicken and one cup of the shredded cheddar cheese to the bowl. Mix thoroughly so the chicken is evenly coated and the cheese is distributed across the filling. This step ensures that every serving contains both protein and richness.
Prepare the biscuits
Open the refrigerated biscuit dough and cut each biscuit into quarters. Add the biscuit pieces to the chicken mixture and gently fold them in. Take care to coat the biscuits without overmixing, allowing them to remain intact so they bake evenly and develop a soft, fluffy texture.
Assemble the casserole
Transfer the mixture into the prepared baking dish, spreading it evenly from edge to edge. Sprinkle the remaining half cup of shredded cheddar cheese over the top, creating a layer that will melt and lightly brown during baking.
Bake the casserole
Place the dish in the preheated oven and bake for 30 to 35 minutes. The casserole is ready when the biscuits are fully cooked, puffed, and golden on top, and the cheese is melted and bubbling across the surface.
Finish with butter
Remove the casserole from the oven and brush the tops of the biscuits with melted butter. This step adds flavor and enhances the final texture, giving the biscuits a soft finish with a lightly glossy appearance.
Serve and enjoy
Allow the casserole to cool slightly before serving. This helps the layers settle and makes portioning easier. Garnish with fresh parsley or chives if desired, adding a touch of color and freshness.
This Chicken Biscuit Casserole works well as a complete meal on its own, though it pairs nicely with simple sides such as a green salad or steamed vegetables. It reheats smoothly and maintains its texture, making it a reliable option for leftovers. Whether prepared for a busy evening or shared with family and friends, this dish offers warmth, flavor, and ease in every serving.
